Best neighbourhood for my second visit.

Went to bangkok 4 months ago and stayed quite central. Did all the typical tourist temples, chinatown, khaoson road etc. Now on my second trip I am hoping to stay in a different neighbourhood - ideally something with a couple of nice bars and restaurants. I have heard mixed reviews about Thonglor so not to sure if that is a good idea. Might also go to Ekkami.

Any suggestions are welcome - thanks.