Should I open Express Entry if my job qualifies in the Category based but possibly low CRS?

Hi so its not me, but my cousin who has been wanting to be PR asked me this question. He’s in Quality Assurance for 7 straight years which we learned falls under STEM (NOC 21222). So we first tried checking CRA Calculator (Kind of guessing the IELTS for with conservative scores), and his points are 455. Which is well below current rounds of invitation.

Is it worth it to go through it, meaning spending for IELTS and ECA and everything given that the score might be not be high enough BUT his job is qualified in the categories?