Struggling with Retatrutide Side Effects (Fatigue, Pain, Anhedonia) – Anyone Tried Daily Dosing?

Hey everyone,

I’ve been on Retatrutide (3mg twice a week) for a little while now, and I’m really struggling with side effects, particularly extreme fatigue, body pain, and anhedonia. The worst part is that the three days following my injections are the most brutal – I feel completely wiped out, and my body feels sore all over. The only time I feel a bit better is around 4 days post-injection, but it's tough to get through the first few days.

I’ve also been on 50mg Vyvanse (though it’s not doing much for me since starting Retatrutide) and TRT (160mg). The Vyvanse still masks some of the fatigue, but I feel like it’s less effective now. I’ve already lost 13lbs on Retatrutide, but I still have about 15lbs to go.

Here’s my question: Has anyone tried daily injections of Retatrutide to see if it helps reduce side effects? I was thinking something like 0.7mg daily to lower the dose and avoid the peaks and valleys I’m experiencing now. I’ve read some anecdotes that the daily dosing might help prevent receptor desensitization, but I’m not sure if it’s worth trying or if it could backfire.

Has anyone had success with daily dosing or have any advice on managing these side effects? I’m open to suggestions!

Thanks in advance for any advice or insights!